It is cited as a milestone in the James Lind Library, which chronicles the evolution of fair tests and research synthesis. I didn’t agree they were moving too slowly – I wrote about why over at The Atlantic – but at least I could see a basis for taking that position.
Peter Doshi | The BMJ Casting doubts on the vaccines with smoke and mirrors, and scaring well-protected people into boosters before they’re needed, are both natural enemies of that absolute goal. The constant saturation of data has fed the perception that only specific epidemiological metrics will allow for the resumption of normal life. People got sick but society continued churning. — The Bad Cat, "It takes a wise doctor to know when not to prescribe."
We're Not in a 'Pandemic of the Unvaccinated,' Peter Doshi Explains ... (The J&J vaccine hasn’t been used as long, and other vaccines are not FDA-approved, so aren’t relevant to the FDA argument.)
[Article] Viral marketing | Harper's Magazine Peter Doshi, a senior editor at The BMJ and associate professor of pharmaceutical health services research at the University of Maryland School of Pharmacy, and Restev Levi, a health system and analytics professor at MIT, expressed doubts about COVID vaccine efficacy and the failures of the scientific community. Again, however, officials put few countermeasures in place, and disruptions to social life hovered somewhere between minimal and nonexistent — reflecting a society largely unaware of the deadly pandemic. Download PDF . “I first became acquainted with Dr. Doshi through his work on the Tamiflu® reviews,” says Godlee. Independent group will evaluate costs for certain new and existing medications and make recommendations about how to curb high drug prices. September 2022 My posts at The Atlantic, at WIRED, and debunking posts at my personal website. The key to ending the pandemic, therefore, isn’t biological. All
The RIAT Support Center aims to accelerate the correction of the scientific record of clinical trials by making publications more accurate and more complete, addressing these problems of publication bias and reporting bias. Research Offices, contracts, investigators, UMB research profile, Services For students, faculty, and staff, international and on-campus, University Life Alerts, housing, dining, calendar, libraries, and recreation. Subscribe now You've read one of your two free articles this month. Trends in Pharmacological Sciences 2013;34(12):645-647.
We'Re Not in A 'Pandemic of The Unvaccinated', Peter Doshi Explains ... (, “Covid-19: Spreading vaccine “misinformation” puts licence at risk, US boards tell physicians” (, Public statement at FDA VRBPAC advisory committee meeting, Sep 17, 2021. Sieluk J, Palasik B, dosReis S, Doshi P. ADHD medications and cardiovascular adverse events in children and adolescents: cross-national comparison of risk communication in drug labeling. Dr. Topol is a professor of molecular medicine at Scripps Research. Dr. Doshi completed a fellowship in comparative effectiveness research at Johns Hopkins University before joining the faculty at the University of Maryland School of Pharmacy. Doshi writes he’s concerned about declining efficacy, “And so the recent reports from Israel’s Ministry of Health caught my eye. For years, researchers have talked about the problem of publication bias, or selectively publishing results of trials. This reality reveals that the “end” to a pandemic can’t be determined by some sort of epidemiological milestone or acquiring a magic-bullet treatment that removes all risk from the virus. (e.g. But as appealing as this notion is in its simple clarity, it clashes with history: Over the past century, the end of respiratory pandemics has never been clear-cut. The University of Maryland, Baltimore is the founding campus of the University System of Maryland. I sure don’t envy the people under all that pressure at the U.S. Food and Drug Administration. Some of them were released after Doshi’s BMJ blog post was published, but many were already available. If there is a strong science-based case to make against the FDA approving the vaccines now, though, this wasn’t it. After making a selection, click one of the export format buttons. The New York Times, . To say a vaccine works should mean that most people no longer run the risk of getting seriously sick. Third, even if the studies are allowed to run past their interim analyses, stopping a trial of 30,000 or 44,000 people after just 150 or so Covid-19 cases may make statistical sense, but it defies common sense. In 2013, the New York Times reported on his work to increase public access to clinical study reports. © 2022-2023 University of Maryland, Baltimore.
Oct 26, 2017 20,440 Jan 11, 2021 #1 Opinion | Four Ways to Fix the Vaccine Rollout (Published 2021) The situation is already devolving into chaos. Peter Doshi, PhD, assistant professor in the Department of Pharmaceutical Health Services Research (PHSR) at the University of Maryland School of Pharmacy, has been named an associate editor of the British Medical Journal (BMJ). As a subscriber, you have 10 gift articles to give each month.
RFK, Jr.: NYT Declines My Letter to the Editor + Peter Doshi: We Need ... Peter Foley, a Gifted Composer Gone Too Soon | The New Yorker '+arguments[1].video:'')+"/?url="+encodeURIComponent(location.href)+"&args="+encodeURIComponent(JSON.stringify([].slice.apply(arguments))),e.parentNode.insertBefore(l,e)}})}(window, document, "script", "Rumble"); Rumble("play", {"video":"vgkwl1","div":"rumble_vgkwl1"}); Peter Doshi is a senior editor at The BMJ and on the News & Views team. Contact Peter, search articles and Tweets, monitor coverage, and track replies from one place. What about the petition to slow down FDA approval? Citation Doshi, P. Topol, E. (2021) Coronavirus Vaccine Trials Could Suffer From Shortcuts. It doesn’t necessarily mean people are no longer protected. Speed vs safety in the FDA’s new drug approvals—speed wins, again.
New York lawyers Steven Schwartz and Peter LoDuca face a June 8 hearing on potential sanctions after a court brief they submitted . Peter Doshi, associate editor Author affiliations pdoshi@bmj.com It seemed a truth universally acknowledged that the human population had no pre-existing immunity to SARS-CoV-2, but is that actually the case? "There are entire countries from the United Kingdom to Japan which do not . In addition, there were differences in who got the boosters – the proportion of people who weren’t Arabic, were originally vaccinated in January rather than February, and/or were over 70 was higher among the booster-vaxed, for example. The BMJ is now more than a scholarly journal, and for the past decade we have pursued investigative journalism as a powerful lever for improving health by exposing failings in the system. Problems with data about high-profile drugs have led to scandals over the past decade, like one involving contentions that the number of heart attacks was underreported in research about the painkiller Vioxx. Dr. Doshi campaigns for greater transparency of clinical trial data and has received wide recognition for his work. doi:10.1136/bmj.f3037 (. Anyone can read what you share. Raw data from clinical trials: within reach? Global Health
Doshi P. Influenza: marketing vaccine by marketing disease. Informed Consent to Study Purpose in Randomized Clinical Trials of Antibiotics, 1991 Through 2011. He is an advocate for greater public access to clinical trial data. To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. “Covid-19 Vaccine Trials” (Public statement at FDA advisory committee (VRBPAC) meeting, Oct 22, 2020; “Will covid-19 vaccines save lives? “And so…[this]…caught my eye”… It’s not often you see someone spell out their own cherry-picking and confirmation bias so explicitly! Knowing how a clinical trial defines its primary endpoint — the measure used to determine a vaccine’s efficacy — is critical to understanding the knowledge it is built to discover. Another involved accusations of misleading data about links between the antidepressant Paxil and the risk of suicide among teenagers. His research focuses on the drug approval process, how the risks and benefits of medical products are communicated, and improving the credibility and accuracy of evidence synthesis and biomedical publications. “Safety and efficacy of a 3rd dose” (, “Transparency of covid vaccine trial data” 8 minute talk in The BMJ’s “Known Unknowns” webinar series (, “Vaccine mandates: a new form of ‘institutional segregation’” (, “Does the FDA think these data justify the first full approval of a covid-19 vaccine?” (, “Transparency of COVID-19 vaccine trials: decisions without data” (, “Covid-19 vaccines for children: hypothetical benefits to adults do not outweigh risks to children” (, Public statement at FDA VRBPAC advisory committee meeting to discuss Covid-19 vaccines in children, June 10, 2021 (, “Why we petitioned the FDA to refrain from fully approving any covid-19 vaccine this year” (, “Covid-19 vaccines: In the rush for regulatory approval, do we need more data?” (, “FDA response to BMJ on reports of death after covid-19 vaccination” (, Public statement at FDA VRBPAC advisory committee meeting to discuss Janssen’s EUA application, Feb 26, 2021 (, “Transparency & Covid-19 vaccines.” 8 minute talk in The BMJ’s Known Unknown webinar series (, “How to Fix the Coronavirus Vaccine Rollout: Don’t Pressure the Vaccine-Hesitant.” (, “Pfizer and Moderna’s “95% effective” vaccines—we need more details and the raw data” (, “Did the FDA understaff its review of the Pfizer/BioNTech vaccine?” (, “How to Expand Access to COVID Vaccines without Compromising the Science” (. “Each meeting left me more impressed with his thoughtfulness, thoroughness, independence, and courage – all qualities that are highly valued at BMJ. These Coronavirus Trials Don’t Answer the One Question We Need to Know, https://www.nytimes.com/2020/09/22/opinion/covid-vaccine-coronavirus.html. April 2023
It's running right through the pews of individual churches, separating people who had long worshipped together. 2012 Apr 10;9(4):e1001201. There may well be insufficient data to address the aged and underrepresented minorities.
Will covid-19 vaccines save lives? Current trials aren't designed to ... Articles by Peter Doshi's Profile - Muck Rack May 2023 The subject was not hospitalized, did not seek further medical care, and did not have risk factors for severe disease”. 2016 Jan;176(1):11-2. Taken together, studies have shown that results of only about half of clinical trials make their way into medical journals. Likelihood of getting tested is another complication. Interprofessionalism
He has been warmly welcomed by his new colleagues.”. The RIAT Support Center aims to accelerate the correction of the scientific record of clinical trials by making publications more accurate and more complete, addressing these problems of publication bias and reporting bias. Doshi also has strong interests in journalism as a vehicle for encouraging better practice and improving the research enterprise. Doshi P. 2017. So let’s put this data into some more accurate perspective before we get to the bunch of other studies on this question that Doshi doesn’t mention. Advocacy
Doshi’s latest argument was mostly about waning immunity against non-severe Covid-19. The virus makes the timeline.”. There are several reasons this is a problem. Earlier this month, he posted a badly flawed "analysis" casting doubt on the efficacy of the Moderna and Pfizer COVID-19 vaccines. Rapid Response to Gupta and colleagues' comments on "Will covid-19 vaccines save lives?
The end of the pandemic will not be televised | The BMJ November 2022
: Rapid response to: Covid-19: re-opening universities is high risk, Peter Doshi: Pfizer and Moderna’s “95% effective” vaccines—let’s be cautious and first see the full data, Peter Doshi: Pfizer and Moderna’s “95% effective” vaccines—we need more details and the raw data, Inaccurate Statement [regarding to statement “Clinical trials have shown that the vaccines authorized for use in the US are highly effective against COVID-19 infection, severe illness, and death.”], Covid-19 vaccines for children: hypothetical benefits to adults do not outweigh risks to children. Over the course of nine months in 1957-1958, an estimated 66,000 excess deaths associated with influenza occurred in the United States and about “80 million Americans were bedridden with respiratory disease,” according to one report. You would want to protect against the worst cases. This was before the Delta variant arrived in force. The people most vulnerable to getting infected or suffering severe disease went first.
Cancer Without Chemotherapy: 'A Totally ... Experiential Learning
Doshi is principal investigator of the RIAT Support Center, which was funded by the Laura and John Arnold Foundation (2017-2022). The End of the Pandemic Will Not Be Televised, Covid-19: Spreading vaccine "misinformation" puts licence at risk, US boards tell physicians, United States. They’ve been at the brunt of an extended media barrage to approve Covid vaccines more quickly.
PLoS Med. For severe Covid-19, the January-vaxed rate was 86%; February-vaxed was 91%; March-vaxed was 94%; April-vaxed was 84% (with very large uncertainty). "An unexpectedly excellent magazine that stands out amid a homogenized media landscape." —the New York Times. And according to the FDA, this person didn’t meet the CDC definition for severe, either. We have reported the disclosures of a whistleblower working on the Pfizer covid-19 vaccine trial, a story that unexpectedly led us to confront Facebook over the way it deals with misinformation on its platform. A video from a recent Committee on Homeland Security and Governmental Affairs meeting featuring Peter Doshi, an associate professor of pharmaceutical health services research at the University of Maryland School of Pharmacy, was removed by YouTube because Doshi was accused of spreading medical misinformation.
Doshi added a “waning immunity” argument, and looped in others he’s made previously – in January, contesting the efficacy of the mRNA vaccines, and then in June, when he and a group of others petitioned the FDA against approving the vaccines until deep into 2022 or 2023 when follow-up for the phase 3 trials is completed. Yet, while the 1918 pandemic may have been years-long on paper — killing three times as many people as covid-19 when adjusted for population — in real life, countermeasures were rarely sustained for longer than six weeks. This newest of new variants has produced widely varying responses, with some suggesting it heralds the end phase of the pandemic and others doubling down on containment measures.
Doshi campaigns for greater transparency of clinical trial data and leads the Restoring Invisible and Abandoned Trials (RIAT) initiative, which aims to ensure clinical trial publications are accurate, complete, and data are publicly available. It is cited as a milestone in the James Lind Library, which chronicles the evolution of fair tests and research synthesis.
When Will the COVID-19 Pandemic End? Previous message: [Sci-tech-public] . It is available here. Much of Dr. Doshi’s research has examined the science and politics of influenza policy. For at least some, a 3-dose course may make an important difference. Peter Doshi Israel is not the only place that has substantial numbers of people vaccinated 6 months ago, and differences in other studies aren’t typically as dramatic as the reports coming from there. That’s true. Current PubMed search results for “Doshi Peter”, Current Google Scholar search results for “Peter Doshi”, Many of Doshi’s publications are available for free through special links listed on the University of Maryland, Baltimore’s Digital Archive. However, we were on opposing sides of a long-running debate about HPV vaccines, and I actively disputed claims from some of his colleagues (Peter Gøtzsche, Carl Heneghan, and Tom Jefferson): that may at some point have included criticism of commentary he co-authored on that vaccine.
Beyond covid, we have tackled concerns in global health, including polio eradication, and asked whether health institutions should still be investing in fossil fuels. 2017 Oct 1;177(10):1452-1459. With BMJ at the forefront of this discussion, it was a great honor to be asked to join their team,” he says. It’s hard to imagine how much higher the stakes can be to get this right. Jefferson T, Jones M, Doshi P, Spencer EA, Onakpoya I, Heneghan CJ. The dividing line isn't just running between congregations. www.nytimes.com If you go down to "Don't Pressure The Vaccine Hesitant," you will see the name "Peter Doshi." How to Expand Access to COVID Vaccines without Compromising the Science: Emergency use authorizations by the FDA are not ideal, Vaccine mandates: a new form of ‘institutional segregation’, How clinically serious is SARS-CoV-2 infection for children and young adults? And we already know all we need to about that single vaxed person counted as severe, because that happened early in the trial, not after several months.
BMJ.
Vaccine efficacy across the whole time was 91% (CI 89-93) against symptomatic disease, and 95% (CI 71-99.9) against severe disease (only 1 vaxed person severely ill versus 21 in the placebo group).
Oseltamivir for influenza in adults and children: systematic review of clinical study reports and summary of regulatory comments. Cellular immunity (non-antibody immunity, such as from T-cells) can help clear an infection without the person getting severely ill. (There’s a good article by Céline Gounder explaining this here.). Your email address will not be published. Small numbers and the short time period mean there’s too much uncertainty about the difference it might have made for severe disease. Helen Branswell reports that the CDC’s vaccination committee was just told that in addition to the over 40,000 people in the phase 3 trial, they are looking at studies with a total of 680,000 people in them. Although the piece contained factual errors and defamatory accusations, the Times declined to publish my letter to the editor correcting those false claims. . A participant receiving an injection during a Phase 3 coronavirus vaccine clinical trial. Make your work accessible to all, without restrictions, and accelerate scientific discovery with options like preprints and published peer review that make your work more Open.
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We may not find out whether the vaccines prevent moderate or severe cases of Covid-19. Research and Innovation. Add your ORCID here. They don’t provide a solid justification for this, especially in a pandemic.
“Though still early in his career, Dr. Doshi has quickly gained the respect of his colleagues around the world for his work to develop solutions that address the problem of reporting biases,” says C. Daniel Mullins, PhD, professor and interim chair of PHSR.
The New York Times publishes HIV-denying, anti-vaxxer freak ... - ResetEra Doshi and I have agreed and disagreed on important issues over the years, but I don’t think I’ve ever criticized his work or views publicly before rebutting his claims about the BNT-Pfizer vaccine in January this year. According to the protocols for their studies, which they released late last week, a vaccine could meet the companies’ benchmark for success if it lowered the risk of mild Covid-19, but was never shown to reduce moderate or severe forms of the disease, or the risk of hospitalization, admissions to the intensive care unit or death. Associate editor at The British Medical Journal and assistant professor of pharmaceutical health services at the University of Maryland. Peter Doshi is an associate professor of pharmaceutical health services research in the School of Pharmacy and associate editor at The BMJ. Save my name, email, and website in this browser for the next time I comment. The Restoring Invisible and Abandoned Trials (RIAT) initiative enables researchers everywhere to address two long-standing problems in the biomedical literature: non-publication and misreporting of trials. But that’s not how the companies testing three of the leading coronavirus vaccine candidates, Moderna, Pfizer and AstraZeneca, whose U.S. trial is on hold, are approaching the problem. Awards and Honors
Perspective | The end of the pandemic won't come from biology or ...
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