[2] The high endometrial activity of dienogest underlies its ability to stabilize the menstrual cycle when combined with either ethinylestradiol or estradiol valerate (which has lower relative effects on the uterus compared to ethinylestradiol) in birth control pills, and also its use in the treatment of endometriosis. [54][55], Dienogest was synthesized in 1979 in Jena, Germany under the leadership of Kurt Ponsold, was initially referred to as STS-557. Use back-up birth control for at least 9 days. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Die Prognose von Alopecia androgenetica (hormonell-erblich bedingter Haarausfall) variiert stark von Person zu Person. Durch die Umstellung des Hormonhaushaltes während den Wechseljahren wird der Haarausfall begünstigt. ", "Estradiol valerate/dienogest - AdisInsight", "Prospective, randomized, double-blind, placebo-controlled phase IIa clinical trial on the effects of an estrogen-progestin combination as add-on to inpatient psychotherapy in adult female patients suffering from anorexia nervosa", "[Pharmacological and clinical profile of dienogest (DINAGEST Tab. Häufig beginnt der Haarausfall oberhalb der Schläfen, wodurch sich sogenannte Geheimratsecken bilden. Dienogest and estradiol will not protect you from sexually transmitted diseases--including HIV and AIDS. [10], Dienogest has progestogenic activity, possibly some antiprogestogenic activity, and has antiandrogenic activity. A dose of 2 mg inhibits the growth of ovarian follicles at 10 mm and maintains the concentration of progesterone at a low level, but has a weak inhibitory effect on FSH and LH. Steroids. It is a birth control pill that contains two types of hormones, estrogens and progestins and, when taken properly, prevents pregnancy. > Expertenrat Aim: Dienogest (DNG) is highly effective for relieving pain caused by endometriosis and adenomyosis. Dienogest reduces the level of endogenous production of oestradiol and thereby suppressing the trophic effects of oestradiol on both the eutopic and ectopic endometrium 6. Also es wächst ein neuer Nagel unter dem alten. 1 mg)]", "Dienogest: a new therapeutic agent for the treatment of endometriosis", "Noncontraceptive benefits of the estradiol valerate/dienogest combined oral contraceptive: a review of the literature", "Contraception containing estradiol valerate and dienogest--advantages, adherence and user satisfaction", "Endometriosis: the effects of dienogest", "Does dienogest influence the inflammatory response of endometriotic cells?  |  Experten  |  Kontakt In a long-term carcinogenicity study involving rats and mice, exposure of 10 times the dose of maximum recommended clinical dose of dienogest resulted in increased incidences of pituitary adenomas, fibroepithelial mammary tumours, stromal polyps of the uterus and malignant lymphoma 6. Generic name: dienogest and estradiol [ dye-EN-oh-jest-and-ESS-tra-DYE-ole ] [56] The first product on the market to contain dienogest was a combined birth control pill (with ethinylestradiol), Valette, introduced in 1995 and made by Jenapharm. Mithilfe von Finasterid lässt sich bei etwa 90 Prozent der Betroffenen ein Fortschreiten des hormonell-bedingten Haarausfalls verhindern, bei etwa 50 Prozent wird zusätzlich eine Verdichtung der Kopfbehaarung bewirkt. [13] In the case of the dienogest and estradiol valerate birth control pill, these other brand names include Gianda and Klaira. 1 Review/update the Zahlreiche Selbsttests regen zur Interaktion an. Use a back-up birth control, such as condoms or a spermicide, for the first 9 days. Methods: Using Health Insurance Review and Assessment Service (HIRA) data generated between 1 January 2010 and 30 June 2018, we identified women with an endometriosis diagnosis code who used GnRH agonists . Dienogest is rapidly absorbed following oral administration, with 91% bioavailability. A meta-analysis of its effectiveness]", Algestone acetophenide (dihydroxyprogesterone acetophenide), Flugestone acetate (flurogestone acetate), Gestonorone caproate (gestronol hexanoate), Segesterone acetate (nestorone, elcometrine), Prasterone (dehydroepiandrosterone, DHEA), Androstanolone (stanolone, dihydrotestosterone, DHT), Drostanolone propionate (dromostanolone propionate), Metenolone enanthate (methenolone enanthate), Oxabolone cipionate (oxabolone cypionate), Trenbolone hexahydrobenzylcarbonate (trenbolone cyclohexylmethylcarbonate), Metandienone (methandienone, methandrostenolone), Normethandrone (methylestrenolone, normethisterone), 17α-Methyl-11-deoxycorticosterone acetate, 16-Methylene-17α-hydroxyprogesterone acetate, 17α-Hydroxyprogesterone (hydroxyprogesterone), Hydroxyprogesterone caproate (hydroxyprogesterone hexanoate), Hydroxyprogesterone heptanoate (hydroxyprogesterone enanthate), Hydroxyprogesterone heptanoate benzilic acid hydrazone, 11β-Methyl-19-nortestosterone dodecylcarbonate, Normethandrone (methylestrenolone, normethandrolone, normethisterone), 11-Deoxycortisone (21-hydroxyprogesterone), 11-Deoxycortisol (17α,21-dihydroxyprogesterone), Adrenosterone (11-ketoandrostenedione, 11-oxoandrostenedione), DHEA (androstenolone, prasterone; 5-DHEA), 7α-Methyl-19-norandrostenedione (MENT dione, trestione), Methylclostebol (chloromethyltestosterone), Andarine (acetamidoxolutamide, androxolutamide, GTx-007, S-4), Enobosarm (ostarine, MK-2866, GTx-024, S-22), https://en.wikipedia.org/w/index.php?title=Dienogest&oldid=1148274116, Creative Commons Attribution-ShareAlike License 3.0, DNG; Dienogestril; Cyanomethyldienolone; BAY 86-5258; Endometrion; M-18575; MJR-35; SH-660; SH-T00660AA; STS-557; ZK-37659; δ, 210 to 218 °C (410 to 424 °F) (experimental), Dienogest 1 mg oral tablets (Dinagest) and 2 mg oral tablets (Valette) (not available in U.S.) – indicated for endometriosis, 2 dark yellow tablets each containing 3 mg estradiol valerate, 5 medium red tablets each containing 2 mg estradiol valerate and 2 mg dienogest, 17 light yellow tablets each containing 2 mg estradiol valerate and 3 mg dienogest, 2 dark red tablets each containing 1 mg estradiol valerate, Dienogest 2 to 3 mg and estradiol valerate 1 to 3 mg oral tablets (Qlaira) (not available in U.S.) – indicated for contraception, Each dark yellow active tablet contains 3 mg estradiol valerate, Each medium red active tablet contains 2 mg estradiol valerate and 2 mg dienogest, Each light yellow active tablet contains 2 mg estradiol valerate and 3 mg dienogest, Each dark red active tablet contains 1 mg estradiol valerate, Dienogest 2 mg and estradiol valerate 1 or 2 mg oral tablets (various) – indicated for menopausal hormone therapy, This page was last edited on 5 April 2023, at 04:22. Drug created at September 23, 2015 16:17 / Updated at June 05, 2023 06:28, Structured drug data for data science & ML, Clinical intelligence tool for your software, Search for drug interactions with our API, Get drug allergy and cross sensitivities info. aliphatic nitrile, 3-oxo Delta(4)-steroid, 17beta-hydroxy steroid, steroid hormone (, G03AB — Progestogens and estrogens, sequential preparations, G03A — HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE, G03 — SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM, G — GENITO URINARY SYSTEM AND SEX HORMONES, G03FA — Progestogens and estrogens, fixed combinations, G03F — PROGESTOGENS AND ESTROGENS IN COMBINATION, G03AA — Progestogens and estrogens, fixed combinations, Combination Contraceptives (with Estrogen and derivatives), Hormones, Hormone Substitutes, and Hormone Antagonists, Progestogens and Estrogens, Sequential Preparations, Sex Hormones and Modulators of the Genital System, Predicted MS/MS Spectrum - 10V, Positive (Annotated), Predicted MS/MS Spectrum - 20V, Positive (Annotated), Predicted MS/MS Spectrum - 40V, Positive (Annotated), Predicted MS/MS Spectrum - 10V, Negative (Annotated), Predicted MS/MS Spectrum - 20V, Negative (Annotated), Predicted MS/MS Spectrum - 40V, Negative (Annotated), LC-MS/MS Spectrum - LC-ESI-QFT , negative, splash10-03di-0019000000-8b6511db078a7ef4a6d7, splash10-0006-0093000000-b1ea74e40f8e85986825, splash10-0006-0390000000-58a5bd49692ab6bd5ef9, splash10-00dl-0950000000-d53345d5771b7bff2bae, splash10-00di-0910000000-6c64873dce18fb49e840, splash10-00di-1910000000-5dd58f138435ec0555a4, LC-MS/MS Spectrum - LC-ESI-QFT , positive, splash10-03di-0009000000-f354babe14ff8cd78da5, splash10-03di-0109000000-aa4e4dd10536f9ed7fb4, splash10-03di-0924000000-0a4b5e59ffb5fd090a1a, splash10-0btl-1910000000-baa05a6be42e71aa9634, splash10-0a4u-2900000000-d615a57fc7b003b3df8d, splash10-05ox-3900000000-17cbf8436dfbbec977c2. Ich brauche einen Gestagen als Gegenspieler, ich komme da nicht drum herum. Dienogest macht BEI MIR Haarausfall und zwar mittlerweile so stark, dass es nicht mehr tolerierbar ist. [2] This is in contrast to gonadotropin-releasing hormone analogues (GnRH analogues), which suppress estradiol levels to lower concentrations and readily induce menopausal-like symptoms. Patients who received DNG maintenance . Dienogest is an oral progestin used for the treatment of endometriosis as monotherapy or contraception in combination with ethinylestradiol. [10] Qlaira was introduced in Europe in 2009 and Natazia was introduced in the United States in 2010. Auch für Dienogest ist noch nicht abschließend geklärt, wie stark das Thromboserisiko ansteigt. Aber ich klebe ja noch das Pflaster dazu. Objective: Endometriosis affects up to 10% of women of reproductive age, and the main goal of treatment is to relieve symptoms. It works by suppressing oestradiol production and preventing the growth of the endometrium. Unser Angebot erfüllt die afgis-Transparenzkriterien. Your risk of stroke or blood clot is highest during your first year of taking dienogest and estradiol. [48][22] It is also unique among most 19-nortestosterone progestins in that it has a double bond between the C9 and C10 positions. [6][7][1][8][9][10] It is also used in menopausal hormone therapy and to treat heavy periods. Vielmehr liegt unser Anspruch darin, die Beziehung zwischen Arzt und Patienten durch die bereitgestellten Informationen qualitativ zu verbessern und zu unterstützen. Wenn das zeitlich begrenzt war, müsste es dann auch bald besser werden. So richtig Sinn macht das für mich ja nicht…. Dienogest and estradiol is used to prevent pregnancy. Aufgrund seiner Affinität zu Zahlen, Daten und Fakten, liegt sein Fokus dabei auf der Beschreibung von relevanten klinischen Studienergebnissen. During Days 18 through 24, throw out the rest of the pack and start a new one the same day. Bei den anderen Gestagenen, außer bei den androgenen, steht das nicht in den Nebenwirkungen. Im weiteren Verlauf wird auch die Behaarung am Oberkopf lichter, bis nur noch ein hinterer oder seitlicher Haarkranz besteht, was als Stirnglatze bezeichnet wird. Estradiol can also affect blood levels of certain other drugs, making them less effective or increasing side effects. The therapeutic efficacy of Acarbose can be decreased when used in combination with Dienogest. [2], Dienogest weakly stimulates the proliferation of MCF-7 breast cancer cells in vitro, an action that is independent of the classical PRs and is instead mediated via the progesterone receptor membrane component-1 (PGRMC1). [2] The medication has some antiandrogenic activity, which may help to improve androgen-dependent symptoms like acne, and has no other important hormonal activity. Zur Behandlung von erblich-bedingtem Haarausfall nach den Wechseljahren können Dienogest, Chlormadinon oder Cyproteron als Einzelpräparate eingesetzt werden. Jenapharm sagt, es stehe bei den Nebenwirkungen dabei, weil es nur wirken könne, wenn der Ausfall und die Akne hormonell bedingt seien. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Aufgrund seiner chemischen Struktur verhält sich Dienogest allerdings eher wie ein . During Days 25 through 28, throw out the rest of the pack. Treatment duration varied widely among the studies, from 6 months to 79 months. Hormonell-erblicher Haarausfall (Alopecia androgenetica). Smoking can greatly increase your risk of blood clots, stroke, or heart attack. InChI=1S/C20H25NO2/c1-19-8-6-16-15-5-3-14(22)12-13(15)2-4-17(16)18(19)7-9-20(19,23)10-11-21/h12,17-18,23H,2-10H2,1H3/t17-,18+,19+,20-/m1/s1, 2-[(10S,11S,14R,15S)-14-hydroxy-15-methyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-1,6-dien-14-yl]acetonitrile, [H][C@@]12CC[C@@](O)(CC#N)[C@@]1(C)CCC1=C3CCC(=O)C=C3CC[C@@]21[H], Use our structured and evidence-based datasets to. Language links are at the top of the page across from the title. Der Haarverlust kann sich auf klar abgegrenzte, kahle Stellen beschränken – bei anderen Betroffenen bleibt bis ins hohe Lebensalter ein Flaum von Wollhaaren (Vellushaaren) am Oberkopf bestehen. Frau Dr. Grüne, ich habe Topiramat gestartet... Ich nehme es 2-3 Monate. Beverley Kugler ist seit November 2018 Ärztin bei ZAVA Deutschland. It is generally highly selective for the progesterone receptor and displays strong progestational effects and moderate antigonadot … Prz Menopauzalny. Das Risiko für eine Thrombose ist in den ersten zwölf Monaten der Einnahme sowie nach einer mehr als vierwöchigen Einnahme-Unterbrechung am höchsten. However, women with severe uterine swelling due to adenomyosis who take DNG usually experience metrorrhagia. [2][7][3] Despite its low affinity for the PR however, dienogest has high progestogenic activity in vivo. In these 6 comparative studies, 338 patients treated with dienogest were compared with 846 controls. Many drugs can interact with birth control pills and make them less effective, which may result in pregnancy. We comply with the HONcode standard for trustworthy health information. [13][11] The following formulations are available:[13][11], The availability of these formulations differs by country (see Availability). Ich möchte das alles immer gerne verstehen. Schade... Da hatte ich gerade mal was und nun geht es schon wieder nicht mehr. [2][3] The metabolites of dienogest are quickly excreted and are said to be mostly inactive. Missing a pill increases your risk of becoming pregnant. Dienogest gehört zu der vierten Pillengeneration, die teilweise auch als "Drospirenon-Generation" bezeichnet wird. Medikamente für Frauen und Männer. Haben Sie eine Ahnung, warum? Out of 41 patients (73%) who had severe pain at enrollment, only 1 patient (1.79%) complained of severe pain at the end of 1 . During Days 1 through 16, skip the missed pills and start with the pill that corresponds to the day you remember you missed your doses. 2011;3:175-84. doi: 10.2147/IJWH.S5633. Stop taking this medicine and tell your doctor if you become pregnant, or if you miss two menstrual periods in a row. Sie haben Fragen? Background: This retrospective cohort study aimed to determine whether there is a difference in reoperation rates between patients who used dienogest (DNG) and patients who did not use DNG. Wir können für die Korrektheit der Daten keine Haftung übernehmen, da die Daten zum Teil automatisch konvertiert wurden. Follow the patient instructions provided with your medicine. Helfen Sie mit Ihrer Bewertung: Ja, dieses Thema ist hilfreich! Dosage form: oral tablet (multiphasic) Dienogest, sold under the brand name Visanne among others, is a progestin medication which is used in birth control pills and in the treatment of endometriosis. C[C@]12CCC3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@]2(CC#N)O, InChI=1S/C20H25NO2/c1-19-8-6-16-15-5-3-14(22)12-13(15)2-4-17(16)18(19)7-9-20(19,23)10-11-21/h12,17-18,23H,2-10H2,1H3/t17-,18+,19+,20-/m1/s1, progesterone receptor membrane component-1, List of progestogens available in the United States, "Pharmacology of estrogens and progestogens: influence of different routes of administration", "Progestogens in menopausal hormone therapy", "TGA eBS - Product and Consumer Medicine Information Licence", "Dienogest - Bayer HealthCare Pharmaceuticals/Mochida Pharmaceutical - AdisInsight", "Gynaecological uses of dienogest alone and in combination with oestrogens", "Antiandrogenic and antimineralocorticoid health benefits of COC containing newer progestogens: dienogest and drospirenone", "Review of the safety, efficacy and patient acceptability of the combined dienogest/estradiol valerate contraceptive pill", "Fertility after discontinuation of treatment with an oral contraceptive containing 30 microg of ethinyl estradiol and 2 mg of dienogest", "An overview of the development of combined oral contraceptives containing estradiol: focus on estradiol valerate/dienogest", "Dienogest for the treatment of endometriosis", "Visanne, tablets, 2 mg Bayer BV, The Netherlands (dienogest)", "Venous thrombosis and hormonal contraception: what's new with estradiol-based hormonal contraceptives? Aber es ist in zur freien Kombination nicht zugelassen. Estradiol valerate and dienogest combination is used to prevent pregnancy. The strong CYP3A4 inhibitors ketoconazole and erythromycin have been found to increase exposure to dienogest by up to 3-fold, whereas the strong CYP3A4 inducer rifampicin (rifampin) was found to decrease steady-state and area-under-curve concentrations of dienogest by 50% and 80%, respectively. It will not help as emergency contraception, such as after unprotected sexual contact. Der Verlauf des Haarausfalls unterscheidet sich bei Männern und Frauen: Bei jedem Mann mit hormonell-erblich bedingtem Haarausfall gibt es leichte Unterschiede beim Verlauf des Haarausfalls. You should not take dienogest and estradiol if you smoke and are over 35 years old. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. It is a birth control pill that contains two types of hormones, estrogens and progestins and, when taken properly, prevents pregnancy. :-( Nicht einfach! Je nach individueller Veranlagung kann eine Behandlung erfolgreich verlaufen oder die Betroffenen sprechen wenig bis überhaupt nicht auf die Therapie an. [2] This is a property that ethinylestradiol does not share with estradiol, because of its resistance to metabolism in the endometrium and hence its greater relative effects in this part of the body. Stop taking this medicine and call your doctor at once if you have: signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance; signs of a blood clot--chest pain, sudden cough, wheezing, coughing up blood, swelling or warmth in one or both legs; heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; liver problems--severe stomach pain, fever, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); a change in the pattern or severity of migraine headaches; symptoms of depression--sleep problems, weakness, tired feeling, mood changes. [35] However, they are associated with a significantly lower risk of venous thromboembolism than birth control pills containing ethinylestradiol and a progestin. Use our structured and evidence-based datasets to unlock new insights and accelerate drug research. Version: 7.01. tranexamic acid, norethindrone, levonorgestrel, medroxyprogesterone, Depo-Provera, Provera, Mirena, Lysteda, dienogest / estradiol, Natazia. If you have been given this drug for some other reason, talk with your doctor for more information. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products.